The aim of the FlyBase project is to provide an openly accessible centralized resource for Drosophila genetic, genomic and functional data. It  is carried out by a consortium of Drosophila researchers and computer scientists at: Harvard University, University of Cambridge (UK), Indiana University and the University of New Mexico.

National Human Genome Research Institute

FlyBase: A Drosophila Genomic and Genetic Database

UK Medical Research Council

National Science Foundation

Biotechnology and Biological Sciences Research Council

Wellcome Trust

Alliance Central: A platform for sustainable development of next generation genome knowledgebases

National Institute of Diabetes and Digestive and Kidney Diseases

Investigating metabolic responses to high sugar diets and the onset of diabetic phenotypes

Medical Research Council

FLYBASE--A DROSOPHILA RELATIONAL DATABASE

FLYBASE: A DROSOPHILA GENOMIC AND GENETIC DATABASE

Data Discovery Engine

Annotation

RNAi knockdown assay

Curation

FlyBase

Fairsharing.org

re3data.org

Drosophila

Conditions of use

Gene Function

Phenotype

The Hepatitis C Virus (HCV) Database Project was initially funded by the Division of Microbiology and Infectious Diseases of the National Institute of Allergies and Infectious Diseases (NIAID). The HCV database group strives to present HCV-associated, hand-annotated genetic data in a userfriendly way, by providing access to the central database via web-accessible search interfaces and supplying a number of analysis tools.

This project is deeply indebted to the HIV Database Group, led by Dr. Bette Korber, for much of its tools, infrastructure and philosophy; the two databases continue to collaborate closely and to share software and resources.

To our users Please note that the HCV database site is no longer funded by NIH. We try to keep the database updated and the tools running, but we cannot guarantee we can quickly resolve problems.

National Institute of Allergy and Infectious Diseases

Los Alamos National Laboratory

PHS HHS

hepatitis C virus infection

Hepacivirus hominis

sequence alignment

data transformation

Hepatitis C Virus Database Project (HCV)

Homo sapiens

Gene Feature

Phylogenetics

Geographic Distribution

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

European Molecular Biology Laboratory

Alzheimer's Research UK

State Secretariat for Education, Research and Innovation

National Institute of General Medical Sciences

PRO: A Protein Ontology in Open Biomedical Ontologies

National Library of Medicine

Linking Text Mining and Data Mining for Biomedical Knowledge Discovery

Delaware INBRE

and the National Science Foundation

National Eye Institute

National Heart Lung and Blood Institute

National Institute of Mental Health

UniProt: A centralized protein sequence and function resource

Gene Ontology Consortium

Protein Knowledge Networks and Semantic Computing for Disease Discovery

NHGRI NIH HHS

UniProt

WormBase is an international consortium of biologists and computer scientists providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C. elegans and related nematodes. Founded in 2000, the WormBase Consortium is led by Paul Sternberg (CalTech), Matt Berriman (The Wellcome Trust Sanger Institute), Sarah Dyer (EBI), and Lincoln Stein (The Ontario Institute for Cancer Research). WormBase is a founding member of the Alliance of Genome Resources Project.

WormBase: a core data resource for C. elegans and other nematodes

NLM NIH HHS

filarial elephantiasis

onchocerciasis

Caenorhabditis elegans

Caenorhabditis brenneri

Caenorhabditis japonica

Caenorhabditis remanei

Pristionchus pacificus

Brugia malayi

Onchocerca volvulus

Strongyloides ratti

Trichuris muris

WormBase

"The Human Immunology Project Consortium (HIPC) program was established in 2010, and renewed in 2015 and in 2022, by the NIAID Division of Allergy, Immunology, and Transplantation as part of the overall NIAID focus on human immunology. Through this program, well-characterized human cohorts are studied using a variety of modern analytic tools, including multiplex transcriptional, cytokine, and proteomic assays; multiparameter phenotyping of leukocyte subsets; assessment of leukocyte functional status; and multiple computational methods. 

Through the HIPC program, centralized research resources and a comprehensive, centralized database will be constructed for use by the greater scientific community. The information gained from the HIPC program will provide a comprehensive understanding of the human immune system and its regulation and will reveal novel associations between components of the immune system and other biological systems, identify novel immune mediators and pathways, establish predictors of vaccine safety in different populations, and enable the rapid evaluation of different vaccine formulations and administration regimens in human populations. This knowledge base will also serve as a foundation for the future study of immune-mediated diseases in the human, such as allergy, asthma, transplant rejection, autoimmune diseases, and a variety of inflammatory diseases."

HIPC Data Coordinating Center

allergic disease

asthma

autoimmune disease

Flow Cytometry

Mass Cytometry

Mass Spectrometry

transcription profiling assay

ImmuneSpace

The NIAID TB Portals Program is a multi-national collaboration for tuberculosis (TB) data sharing and analysis to advance TB research. As a global consortium of clinicians, scientists, and IT professionals, we built the TB Portals, a web-based, open-access repository of multi-domain TB data and tools for its analysis. Here, you can find linked socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from over 11400 international TB patient cases. You can explore and analyze these data through any of our tools, focusing on only one domain or across all of them. TB Portals data are also available for download to support your own research.

NIAID

FIC NIH HHS

Biothings API

tuberculosis

Mycobacterium tuberculosis

Imaging

Whole genome sequencing

clinical data

TB Portals

TB Portals Data Use Agreement

age at onset

treatment outcome measurement

drug resistance

fibrosis

lung measurement

Comorbidity

The Immunological Genome Project (ImmGen) is a collaborative group of immunology and computational biology labs who join forces and expertise to perform a broad and deep dissection of the genome’s activity and its regulation in the immune system of the mouse. The project defines gene expression signatures and modules, regulatory elements in the genome, their connectivity, and the factors that control them. This as shaped by differentiation, genetic variation and immunologic challenges. These data support the computational reconstruction of the genetic regulatory network underlying immunocyte differentiation and activation. ImmGen is primarily intended as a public resource. The data and metadata are publicly accessible through ImmGen’s dedicated interfaces.

NK Cell Receptors and Their Ligands

NK and T Cell Costimulation by NKG2D/DAP10

National Cancer Institute

RAE-1 Family of Proteins in Innate and Adaptive Immunity

ImmGen: a gene expression compendium for immune cells

LIVER CORE CENTER

NIAID NIH HHS

Immunological detection and control of experimental uncomplicated malaria

MACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERY

immune system disorder

infectious disease

Healthy

Bacteria

high throughput transcription profiling by microarray

RNA-seq assay

assay for transposase-accessible chromatin using sequencing

fluorescence-activated cell sorting method

Immunological Genome Project

Mus musculus

transcriptome measurement

Sequence

cell type

cell count

The Database of Antimicrobial Activity and Structure of Peptides (DBAASP) has been created to provide users with detailed information on experimentally tested peptides regarding their chemical structure and activity against specific targets. The database is manually curated and contains information on ribosomal, nonribosomal, and synthetic peptides that show antimicrobial activity as Monomers, Multimers, and Multi-Peptides.

Fungi

Minimum Inhibitory Concentration Test

cytotoxicity assay

3D structure prediction

Database of Antimicrobial Activity and Structure of Peptides

Hemolysis

cytotoxicity measurement

Peptide Conformation

The HIV Vaccine Trials Network (HVTN) is the world’s largest publicly funded international collaboration facilitating the evaluation of vaccines to prevent HIV/AIDS. The HVTN helps advance the fields of vaccinology, social and behavioral sciences, statistics, and immunology, as well as tuberculosis and COVID-19 vaccines.

Bill and Melinda Gates Foundation

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute of Dental and Craniofacial Research

Leadership Group for a Global HIV Vaccine Clinical Trials Network

NIH Office of the Director

Leadership for HIV/AIDS Clinical Trials Networks; HIV Vaccine Trials Network

HVTN Laboratory Program

HIV infectious disease

COVID-19

AIDS

Severe acute respiratory syndrome coronavirus 2

Human immunodeficiency virus type 1

Human immunodeficiency virus 2

Clinical Trial

Disease Screening

HIV Vaccine Trials Network

Adverse Event

Vaccine Efficacy

Treatment Regimen

The Electron Microscopy Data Bank (EMDB) is a public repository for cryogenic-sample Electron Microscopy (cryoEM) volumes and representative tomograms of macromolecular complexes and subcellular structures. It covers a variety of techniques, including single-particle analysis, helical reconstruction, electron tomography, subtomogram averaging, and electron crystallography (for more information, see the EMDB Policies). 

AMED

NBDC

Ministry of Electronics and Information Technology

Unified Data Resource for Large Complexes Determined by Cryo-Electron Microscopy

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